Protective Role of Granulocyte Colony Stimulating Factor and Umbelliferone on Testes

Abstract

Granulocyte-colony stimulating factor (G-CSF) is a glycoprotein with hormone-like properties. G-CSF organizes proliferation, differentiation, and survival of haemopoietic progenitor cells. Clinically, G-CSF is an approved drug for treatment of leukocytopenia and for mobilization of haemopoietic stem cells from bone marrow towards peripheral circulation. Recently, growing evidence support that G-CSF has many important non haemopoietic functions in other tissues Umbelliferone (UMB) (7-hydroxycoumarin) is a natural product found in plants of the Rutaceae and Umbelliferae families. UMB possesses several pharmacological activities, including antioxidant, anti-inflammatory, antidiabetic, and antiapoptotic effects. The antioxidant and radical scavenging activity of UMB has been reported in several studies by reducing cellular oxidative stress by decrease ROS generation and increase expression of antioxidant enzymes. Also, UMB ability to work locally within the testes to improve the spermatogenesis or centrally by regulating the pituitary-gonadal axis.