Role of Serum Tubulin Alpha 1C in Pathogenesis of Inflammation
Keywords:
Tubulin Alpha 1C, Inflammation, Microtubules.Abstract
Background: The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. They share 40% amino acid sequence identity, exist in several isotype forms.Tubulin-α1-C, also known as tubulin alpha-6, is one of the alpha-tubulin family members. There are three different isoforms of tubulin-α1-C in human tissues, tubulin-α1-C isoform a, b, and c. Tubulin-α-1c might bind to its antigen on cell surface and induce inflammatory response and exacerbate tissue damage. Binding of the Tubulin-α-1 tubulin to epithelial cells resulted in the increased expression of TCF5, which induced downstream proinflammatory cytokines such as VEGF and sustained local tissue inflammation.
Objective: find out the role of serum tubulin alpha-1c in pathogenesis of inflammation and might be a novel biomarker with promising sensitivity and specificity in inflammation.
Methods: The systematic literature review was performed using The PubMed, Google Scholar, Science Direct and the Medline for information on tubulin alpha-1c identification and its role in inflammation between 2006 and 2022 was included, The authors also evaluated references from relevant literature. Documents were in English, and unpublished manuscripts, oral presentations, and conference abstracts were excluded because they were not related to important scientific studies.
Conclusion: our results concluded that tubulin-α-1c has an important role in the pathogenesis of inflammation and may be used in the future as marker of inflammation. long term follow up is required to identify the role of tubulin-α-1c and confirm whether it can be used as a predictor of inflammation.