Advances in the Regenerative Management of Striae Distensae: A Comparative Review of Fluid Platelet-Rich Fibrin and Platelet-Rich Plasma

Abstract

Background: Striae distensae, commonly referred to as stretch marks, are a widespread dermatological concern with significant psychosocial implications, especially among adolescents, pregnant women, and individuals undergoing rapid body changes. Despite being benign, their visible and sometimes extensive appearance can impact self-esteem and quality of life, prompting the search for more effective therapies. Traditional treatments including topical agents, micro-needling, and laser therapy often provide inconsistent results, highlighting the need for innovative approaches. Over recent years, regenerative therapies using autologous blood products have gained prominence in dermatology. Among these, platelet-rich plasma (PRP) and fluid platelet-rich fibrin (f-PRF) have attracted significant attention for their abilities to stimulate tissue repair and remodeling via high concentrations of growth factors and bioactive molecules. PRP is a well-established treatment, known for enhancing collagen production and skin regeneration. f-PRF, a newer, second-generation concentrate, is characterized by a higher yield of platelets and leukocytes, as well as a sustained release of growth factors due to its natural fibrin matrix. This review aims to critically compare the efficacy, mechanisms, clinical outcomes, safety, and patient satisfaction associated with PRP and f-PRF in the management of striae distensae. Through an analysis of the current literature and clinical data, the review identifies existing gaps in knowledge and highlights the need for standardized protocols and larger-scale studies. In conclusion, both PRP and f-PRF represent promising advances in the regenerative management of striae distensae, with f-PRF showing potential for enhanced efficacy due to its unique biological profile. Further research is warranted to establish the optimal treatment modalities and improve patient outcomes.