Erythroferron as a Regulator of Erythropeisis and its Role in Anemia of Chronic Kidney Disease Children Patients

Abstract

Erythroferrone (ERFE) is a recently identified erythroid hormone that bridges erythropoiesis and iron metabolism by regulating hepcidin, the master iron-regulatory peptide. Since its discovery, ERFE has drawn attention for its potentiality as a biomarker of erythropoietic activity, particularly in conditions such as chronic kidney disease (CKD) and β-thalassemia.