Different Azithromycin Protocols in Preterm Premature Rupture of Membranes

Abstract

Preterm premature rupture of membranes (PPROM) is a major obstetric complication associated with increased risks of maternal infection, neonatal morbidity, and preterm birth. Antibiotic therapy is commonly used to prolong pregnancy latency and reduce infectious complications. Azithromycin has emerged as a potential alternative to erythromycin in latency antibiotic regimens due to its favorable pharmacokinetic profile, broad antimicrobial spectrum, and better tolerability. Several recent studies and clinical guidelines have explored different azithromycin protocols for the management of PPROM, with varying dosing strategies and durations of treatment.